Newsome D A, Gross J
Cell. 1979 Apr;16(4):895-900. doi: 10.1016/0092-8674(79)90104-1.
After three or more passages, stromal cell outgrowths from explants of normal rabbit corneas and from corneas previously burned with alkali did not produce collagenase until they were stimulated by the addition of rabbit blood-derived mononuclear cells or media conditioned by them. Normal stromal cells required stimulation by lymphocytes or their products from alkali-burned animals, whereas those from alkali-burned corneas were stimulated by lymphocytes from either normal or alkali-burned rabbits.
经过三次或更多次传代后，正常兔角膜外植体以及先前用碱烧伤的角膜的基质细胞生长物在添加兔血来源的单核细胞或由其条件培养的培养基刺激之前不会产生胶原酶。正常基质细胞需要来自碱烧伤动物的淋巴细胞或其产物的刺激，而来自碱烧伤角膜的基质细胞则受到来自正常或碱烧伤兔的淋巴细胞的刺激。
