Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
J Rheumatol. 2012 Mar;39(3):504-9. doi: 10.3899/jrheum.110983. Epub 2012 Jan 15.
To assess the utility of interferon-α (IFN-α) in serum and cerebrospinal fluid (CSF) as a biomarker of disease activity in central neuropsychiatric systemic lupus erythematosus (cNPSLE).
Serum and CSF samples were drawn at hospitalization in 34 patients with cNPSLE, 16 surgical SLE, 4 primary neuropsychiatric conditions, and 25 with nonautoimmune conditions, except in 44 non-NPSLE patients in whom only serum was studied. Six months later, serum/CSF and serum samples were taken in 20 cNPSLE and 35 non-NPSLE patients, respectively. SLE activity was assessed at hospitalization, and 6 months later in cNPSLE and non-NPSLE patients. IFN-α was detected by Luminex technology.
The mean ± SD age of patients with cNPSLE was 31.4 ± 12.2 years, which was similar across the study groups (p = 0.46). Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores among cNPSLE, non-NPSLE, and SLE-surgical patients were 15.3 ± 8.2, 12.4 ± 8.2, and 3.8 ± 1.5, respectively. IFN-α levels in serum were higher in cNPSLE than in nonautoimmune patients (p = 0.02), but were similar to non-NPSLE and SLE-surgical groups. In CSF samples, IFN-α levels were higher in cNPSLE than in nonautoimmune patients (p = 0.03), and were nonsignificantly higher than in SLE-surgical and primary neuropsychiatric patients. Six months later, serum levels of IFN-α did not vary from baseline values despite a significant decrease in SLEDAI-2K score in cNPSLE and non-NPSLE patients. IFN-α levels in the CSF of patients with cNPSLE also remained stable. Among specific cNPSLE syndromes, CSF IFN-α levels were significantly higher among patients with acute confusional syndrome.
IFN-α does not seem to represent a useful biomarker of cNPSLE syndromes; its utility in specific cNPSLE manifestations merits further investigation.
评估干扰素-α（IFN-α）在血清和脑脊液（CSF）中的作用，作为中枢神经精神性系统性红斑狼疮（cNPSLE）疾病活动的生物标志物。
在 34 例 cNPSLE 患者、16 例手术性 SLE 患者、4 例原发性神经精神疾病患者和 25 例非自身免疫性疾病患者住院期间采集血清和 CSF 样本，除了 44 例非 NPSLE 患者只检测血清外。6 个月后，分别在 20 例 cNPSLE 和 35 例非 NPSLE 患者中采集血清/CSF 和血清样本。在住院期间和 6 个月后评估 SLE 活动度，cNPSLE 和非 NPSLE 患者。通过 Luminex 技术检测 IFN-α。
cNPSLE 患者的平均年龄±标准差为 31.4±12.2 岁，在各研究组之间相似（p=0.46）。cNPSLE、非 NPSLE 和手术性 SLE 患者的系统性红斑狼疮疾病活动指数 2000（SLEDAI-2K）评分分别为 15.3±8.2、12.4±8.2 和 3.8±1.5。cNPSLE 患者血清 IFN-α水平高于非自身免疫性患者（p=0.02），但与非 NPSLE 和手术性 SLE 组相似。在 CSF 样本中，cNPSLE 患者的 IFN-α水平高于非自身免疫性患者（p=0.03），与手术性 SLE 和原发性神经精神疾病患者相比无显著差异。6 个月后，尽管 cNPSLE 和非 NPSLE 患者的 SLEDAI-2K 评分显著下降，但血清 IFN-α水平与基线值相比无变化。cNPSLE 患者 CSF 中的 IFN-α水平也保持稳定。在特定的 cNPSLE 综合征中，急性意识模糊综合征患者的 CSF IFN-α 水平显著升高。
IFN-α似乎不能作为 cNPSLE 综合征的有用生物标志物；其在特定的 cNPSLE 表现中的作用值得进一步研究。
