Transplantation-Oncology Infectious Diseases Program, Weill Cornell University Medical Center, 1300 York Avenue, New York, NY 10065, USA. thw2003@medcornelledu
Clin Infect Dis. 2012 Feb;54 Suppl 1:S1-4. doi: 10.1093/cid/cir862.
Invasive mucormycosis comprises a group of uncommon but emerging life-threatening pulmonary, sinal, rhinocerebral, and disseminated infections, which cause debilitating morbidity and severe mortality in our most vulnerable pediatric and adult immunocompromised patients. While important advances are being achieved in understanding the epidemiology, molecular taxonomy, pathogenesis, pharmacology, host defenses, and microbiology of these infections, there are critical needs for improving these approaches for diagnosis, treatment, and prevention. This supplement is dedicated to the memory and courage of Hank Schueler, who fought valiantly against this infection. It provides a comprehensive resource for current approaches to management of this infection and also reviews the key advances against invasive mucormycosis.
侵袭性毛霉菌病包括一组罕见但正在出现的危及生命的肺部、鼻窦、鼻颅和播散性感染，这些感染使我们最脆弱的儿科和成年免疫功能低下患者遭受严重的发病率和高死亡率。虽然在理解这些感染的流行病学、分子分类学、发病机制、药理学、宿主防御和微生物学方面取得了重要进展，但在改进这些诊断、治疗和预防方法方面仍存在迫切需求。本增刊是为了纪念和赞扬汉克·舒勒（Hank Schueler）而设立的，他勇敢地与这种感染作斗争。它为这种感染的管理提供了全面的资源，同时也回顾了对抗侵袭性毛霉菌病的关键进展。
