Department of Pediatric Hematology/Oncology and Center for Bone Marrow Transplantation, University Hospital of Münster, Münster, Germany.
Mycoses. 2011 Nov;54(6):e785-8. doi: 10.1111/j.1439-0507.2011.02025.x. Epub 2011 May 30.
Mucormycosis is associated with high morbidity and mortality and is perceived as an emerging fungal infection. However, contemporary paediatric data are limited. We present a series of paediatric cases of mucormycosis reported from Germany and Austria collected within a voluntary epidemiological survey through standardised, anonymized case report forms. Twelve cases were reported between January 2004 and December 2008 (six men; mean age: 12.6 years, range: 0.1-17 years). Mucormycosis was proven in nine, and probable in three cases. Isolates included Lichtheimia (syn. Absidia pro parte, Mycocladus) (five), Rhizopus (three) and Mucor (one) species. Infection was limited to soft tissue in three cases, the lung in two cases, and an infected thrombus in one case; rhinocerebral disease was found in three cases, and pulmonary-mediastinal, pulmonary-cerebral and soft tissue-cerebral involvement in one case each. All three patients with isolated soft tissue infection were cured, whereas seven of the remaining patients died (one patient without follow-up). The overall mortality rate was 67%. While these data cannot provide conclusive data on incidence and disease burden of mucormycosis in paediatric patients, they reflect the continuing threat of these infections to immunocompromised patients and the need for improved diagnosis and management.
毛霉病与高发病率和死亡率相关，被认为是一种新兴的真菌感染。然而，目前关于儿科的数据有限。我们报告了德国和奥地利在自愿性流行病学调查中通过标准化、匿名病例报告表收集的一系列儿科毛霉病病例。2004 年 1 月至 2008 年 12 月期间报告了 12 例病例（男性 6 例；平均年龄 12.6 岁，范围 0.1-17 岁）。9 例确诊为毛霉病，3 例疑似病例。分离株包括亮菌属（拟名：伞枝犁头霉，丛梗孢科）（5 例）、根霉属（3 例）和毛霉属（1 例）。3 例感染局限于软组织，2 例感染肺部，1 例感染感染性血栓；3 例为鼻颅疾病，1 例为肺纵隔疾病，1 例为肺脑疾病，1 例为软组织脑疾病。单纯软组织感染的 3 例患者均治愈，而其余 7 例患者死亡（1 例患者无随访）。总死亡率为 67%。虽然这些数据不能提供儿科患者毛霉病发病率和疾病负担的结论性数据，但它们反映了这些感染对免疫功能低下患者的持续威胁，以及需要改进诊断和管理。
