Ogawa Y, Hong S S, Toyosawa S, Chang C K, Yagi T
Department of Oral Pathology, Osaka University Faculty of Dentistry, Japan.
Cancer. 1990 Nov 15;66(10):2111-7. doi: 10.1002/1097-0142(19901115)66:10<2111::aid-cncr2820661012>3.0.co;2-q.
The immunoreactivity for class II antigens of the major histocompatibility complex and interleukin-1 (IL-1) in Warthin's tumor (WT) cells was studied. In addition to macrophages, dendritic cells, and capillary endothelia, the luminal tumor cells and some keratinocytes in the metaplastic squamous foci exhibited immunoreactivity for both class II antigens and IL-1. The distribution of the class II antigens in the luminal tumor cells was limited to their basolateral membrane. These data, together with previous findings, strongly suggest that the luminal tumor cells of WT introduce the luminal antigen to the underlying lymphoid tissue and, thus, act as an antigen-presenting cell.
研究了沃辛瘤（WT）细胞中主要组织相容性复合体II类抗原和白细胞介素-1（IL-1）的免疫反应性。除巨噬细胞、树突状细胞和毛细血管内皮外，化生鳞状病灶中的管腔内肿瘤细胞和一些角质形成细胞对II类抗原和IL-1均表现出免疫反应性。II类抗原在管腔内肿瘤细胞中的分布仅限于其基底外侧膜。这些数据与先前的研究结果一起，强烈表明WT的管腔内肿瘤细胞将管腔抗原呈递给下方的淋巴组织，因此，起到抗原呈递细胞的作用。
