Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia.
J Clin Exp Neuropsychol. 2012;34(4):345-58. doi: 10.1080/13803395.2011.643227. Epub 2012 Jan 17.
The aim of this study was to validate the CogState Brief Battery, which assesses psychomotor, attentional, working memory, and visual learning functions, in healthy older people and in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. In healthy older adults, weak relationships between demographic variables (e.g., education, depression) and cognitive performance were observed. In AD and MCI groups, the magnitude of impairment was greatest for tasks of working memory and memory, with a negative influence of apolipoprotein E ϵ4 status on learning but not working memory. These results suggest that the CogState Brief Battery can be used to screen for AD-related cognitive changes.
本研究旨在验证 CogState 简明电池，该电池可评估健康老年人以及澳大利亚成像、生物标志物和生活方式 (AIBL) 研究中轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 患者的运动、注意力、工作记忆和视觉学习功能。在健康的老年人中，观察到人口统计学变量（例如教育、抑郁）与认知表现之间的关系较弱。在 AD 和 MCI 组中，工作记忆和记忆任务的损伤程度最大，载脂蛋白 E ϵ4 状态对学习但不对工作记忆有负面影响。这些结果表明，CogState 简明电池可用于筛查与 AD 相关的认知变化。
