The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
The 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Theranostics. 2020 Mar 4;10(9):4183-4200. doi: 10.7150/thno.43481. eCollection 2020.
Tumorigenesis is a multistep process characterized by the acquisition of genetic and epigenetic alterations. During the course of malignancy development, tumor cells acquire several features that allow them to survive and adapt to the stress-related conditions of the tumor microenvironment. These properties, which are known as hallmarks of cancer, include uncontrolled cell proliferation, metabolic reprogramming, tumor angiogenesis, metastasis, and immune system evasion. Zinc-finger protein Yin Yang 1 (YY1) regulates numerous genes involved in cell death, cell cycle, cellular metabolism, and inflammatory response. YY1 is highly expressed in many cancers, whereby it is associated with cell proliferation, survival, and metabolic reprogramming. Furthermore, recent studies also have demonstrated the important role of YY1-related non-coding RNAs in acquiring cancer-specific characteristics. Therefore, these YY1-related non-coding RNAs are also crucial for YY1-mediated tumorigenesis. Herein, we summarize recent progress with respect to YY1 and its biological implications in the context of hallmarks of cancer.
肿瘤发生是一个多步骤的过程，其特征在于遗传和表观遗传改变的获得。在恶性肿瘤发展过程中，肿瘤细胞获得了使其能够存活并适应肿瘤微环境应激相关条件的多种特征。这些被称为癌症特征的特性包括不受控制的细胞增殖、代谢重编程、肿瘤血管生成、转移和免疫系统逃逸。锌指蛋白 Yin Yang 1（YY1）调节涉及细胞死亡、细胞周期、细胞代谢和炎症反应的许多基因。YY1 在许多癌症中高度表达，与细胞增殖、存活和代谢重编程有关。此外，最近的研究还表明，YY1 相关的非编码 RNA 在获得癌症特异性特征方面也具有重要作用。因此，这些 YY1 相关的非编码 RNA 对于 YY1 介导的肿瘤发生也至关重要。本文总结了 YY1 的最新研究进展及其在癌症特征背景下的生物学意义。
