Department of Urology, Medical Faculty, Inonu University, Malatya, Turkey.
Andrologia. 2012 Aug;44(4):226-9. doi: 10.1111/j.1439-0272.2011.01271.x. Epub 2012 Jan 16.
Information on male potency in testicular cancer (TC) patients treated with chemotherapy is insufficient. We aimed to assess the levels of depression and anxiety symptoms, sexual function and gonodotrophins. Participants (n = 27) were identified and recruited from the genitourinary services of two medical centres, one in Inonu University and the other in the Firat University. All patients are TC patients treated with chemotherapy after unilateral orchiectomy. Participants completed follow-up assessments after the completion of the chemotherapy regimen. Serum luteinising hormone, follicle-stimulating hormone and testosterone levels were determined after blood samples had been taken in the morning after an overnight fast. International Index of Erectile Function (IIEF-15) was also used to evaluate erectile dysfunction (ED) score. Beck Depression and Beck Anxiety Scale were used to assess psychological symptoms. The findings indicated that men treated with chemotherapy had significantly different IIEF-15 and Beck Anxiety scores compared with men who did not receive chemotherapy. But no statistically significant difference was determined in the serum gonodotrophin levels and depression score between the two groups. It is concluded that patients with TC undergoing chemotherapy have greater risk than normal men for ED, independently of the gonodotrophin's level.
有关接受化疗的睾丸癌（TC）患者男性生育力的信息不足。我们旨在评估抑郁和焦虑症状、性功能和促性腺激素水平。参与者（n=27）从两个医学中心的泌尿生殖服务部门确定并招募，一个在因纽努大学，另一个在菲拉特大学。所有患者均为单侧睾丸切除术后继发化疗的 TC 患者。参与者在完成化疗方案后进行随访评估。在禁食过夜后，早上采集血样后测定血清黄体生成素、卵泡刺激素和睾酮水平。还使用国际勃起功能指数（IIEF-15）评估勃起功能障碍（ED）评分。贝克抑郁和贝克焦虑量表用于评估心理症状。研究结果表明，与未接受化疗的男性相比，接受化疗的男性 IIEF-15 和贝克焦虑评分存在显著差异。但两组之间的血清促性腺激素水平和抑郁评分无统计学差异。研究结论是，接受化疗的 TC 患者发生 ED 的风险高于正常男性，而与促性腺激素水平无关。
