金黄色葡萄球菌5型荚膜多糖的结构
Structure of the type 5 capsular polysaccharide of Staphylococcus aureus.
作者信息
Moreau M, Richards J C, Fournier J M, Byrd R A, Karakawa W W, Vann W F
机构信息
Office of Biologics Research and Review, Food and Drug Administration, Bethesda, Maryland 20892.
出版信息
Carbohydr Res. 1990 Jul 1;201(2):285-97. doi: 10.1016/0008-6215(90)84244-o.
The Staphylococcus aureus type 5 capsular polysaccharide is composed of 2-acetamido-2-deoxy-L-fucose (1 part), 2-acetamido-2-deoxy-D-fucose (1 part), and 2-acetamido-2-deoxy-D-mannuronic acid (1 part). On the basis of methylation analysis, optical rotation, high-field one- and two-dimensional 1H- and 13C-n.m.r. experiments, and selective cleavage with 70% aqueous hydrogen fluoride, the polysaccharide was found to be a partially O-acetylated (50%) polymer of the repeating trisaccharide unit, [----4)-3-O-Ac-beta-D-ManpNAcA-(1----4)-a-L-FucpNAc-(1----3) -beta-D-FucpNAc-(1----]n.
金黄色葡萄球菌5型荚膜多糖由2-乙酰氨基-2-脱氧-L-岩藻糖（1份）、2-乙酰氨基-2-脱氧-D-岩藻糖（1份）和2-乙酰氨基-2-脱氧-D-甘露糖醛酸（1份）组成。基于甲基化分析、旋光、高场一维及二维1H和13C核磁共振实验以及用70%氟化氢水溶液进行的选择性裂解，发现该多糖是重复三糖单元[----4)-3-O-乙酰基-β-D-甘露糖醛酸-N-乙酰基-(1----4)-α-L-岩藻糖-N-乙酰基-(1----3)-β-D-岩藻糖-N-乙酰基-(1----]n的部分O-乙酰化（50%）聚合物。
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