Laboratory of Cancer Biology, Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, UK.
Oncogene. 2012 Oct 4;31(40):4343-52. doi: 10.1038/onc.2011.603. Epub 2012 Jan 16.
The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression. Recent findings have revealed new levels of complexity reflecting a repertoire of post-translational modifications that occur on pRb together with its key effector E2F-1. Here we provide an overview of the modifications and consider the possibility of a 'code' that endows pRb with the ability to function in diverse physiological settings.
细胞增殖失控是肿瘤发生的一个标志。视网膜母细胞瘤蛋白（pRb）途径是细胞周期调控和肿瘤抑制的关键组成部分。最近的发现揭示了新的复杂性水平，反映了 pRb 及其关键效应因子 E2F-1 上发生的一系列翻译后修饰。本文概述了这些修饰，并探讨了赋予 pRb 在不同生理环境中发挥功能的“密码”的可能性。
