Jordan University of Science and Technology, Irbid, Jordan.
Hum Exp Toxicol. 2012 Aug;31(8):820-9. doi: 10.1177/0960327111432505. Epub 2012 Jan 16.
Rapid intravenous administration of D-ribose may result in a significant reduction in cellular damage in patients with sudden ischemic insults. The development of an effective and clinically safe therapeutic regimen using the intravenous route in critically ill patients especially with cardiac diseases requires a comprehensive assessment of potential toxic effects of the drug in laboratory animals and in human beings. The potential clinical, behavioral, hematological, biochemical, gross pathological and histological toxic effects associated with the intravenous administration of D-ribose in rabbits for 28 days were evaluated in this study. Except for an increase in neutrophil percentage in male rabbits in the D-ribose-treated groups, there were no statistically significant toxic effects induced by daily intravenous administration of the drug in male and female rabbits. Results of this study suggest that D-ribose administered intravenously for 28 days in the rabbit exhibited no toxicity at 420 mg/kg.
快速静脉输注 D-核糖可能会导致突发性缺血性损伤患者的细胞损伤显著减少。在危重病患者中，特别是患有心脏病的患者中，通过静脉途径开发有效且临床安全的治疗方案，需要全面评估药物在实验室动物和人类中的潜在毒副作用。本研究评估了在 28 天内给兔子静脉注射 D-核糖后，与临床、行为、血液学、生化、大体病理学和组织学相关的潜在毒副作用。除了雄性兔子的中性粒细胞百分比增加外，雄性和雌性兔子每天静脉注射该药物并未引起统计学上显著的毒性作用。本研究结果表明，兔子静脉注射 D-核糖 28 天，在 420mg/kg 时没有表现出毒性。
