Li Shuai, Wang Juanjing, Xiao Yutian, Zhang Li, Fang Jinren, Yang Nanyang, Zhang Zhixia, Nasser Moussa Ide, Qin Hui
Institute of Cytology and Genetics, Hengyang Medical College, University of South China, Hengyang, Hunan 421000, P.R. China.
School of Pharmaceutical Science, University of South China, Hengyang, Hunan 421000, P.R. China.
Exp Ther Med. 2021 May;21(5):496. doi: 10.3892/etm.2021.9927. Epub 2021 Mar 17.
The quality of life of patients with certain diseases may be improved through the development of technologies and advancements in pharmacology, with the aim of prolonging their life. However, congestive heart failure (CHF), as well their complications, continue to be the leading cause of disease-associated death. The mechanisms underlying the development and progression of diabetes and CHF have been uncovered in a stepwise manner and the understanding of these mechanisms has improved the management of these diseases, resulting in reduced mortality and morbidity rates; however, CHF remains the leading cause of death worldwide, particularly in developed countries. In the past decades, research has indicated that several supplements and naturally occurring compounds may be used to treat muscle weakness, for cardiac failure management, rehabilitation following myocardial ischemia-reperfusion and various complications of diabetes. D-ribose is an essential component of the respiratory, skeletal and nervous systems and is a popular compound, as its supplementation may have beneficial effects. In the present review, the physiological roles, toxic reactions and the potential use of D-ribose in the management of clinical diseases are summarized.
通过技术发展和药理学进步，某些疾病患者的生活质量可能会得到改善，目的是延长他们的生命。然而，充血性心力衰竭（CHF）及其并发症仍然是疾病相关死亡的主要原因。糖尿病和CHF发生及进展的潜在机制已逐步被揭示，对这些机制的理解改善了这些疾病的管理，导致死亡率和发病率降低；然而，CHF仍然是全球尤其是发达国家的主要死亡原因。在过去几十年中，研究表明，几种补充剂和天然存在的化合物可用于治疗肌肉无力、管理心力衰竭、心肌缺血再灌注后的康复以及糖尿病的各种并发症。D-核糖是呼吸、骨骼和神经系统的重要组成部分，是一种受欢迎的化合物，因为补充它可能有有益作用。在本综述中，总结了D-核糖的生理作用、毒性反应及其在临床疾病管理中的潜在用途。
