Kyono ART Clinic, 3F, 1-1-1, Honcho, Aobaku, Sendai, Miyagi 980-0014, Japan.
J Assist Reprod Genet. 2012 Mar;29(3):255-7. doi: 10.1007/s10815-011-9707-5. Epub 2012 Jan 17.
To report the world's first case of live monozygotic dichorionic diamniotic (DD) twins after a single vitrified-warmed blastocyst transfer in a cycle during which hormone supplements were given.
The patient was a 39-year-old woman with tubal factor infertility. Six oocytes were retrieved and three blastocysts were vitrified after insemination with her husband's sperm. Two months later, a single warmed blastocyst was transferred on the fifth day after progesterone supplementation during the luteal phase. Two gestational sacs and fetuses with heartbeats showing lambda sign under ultrasonography were recognized at 7 weeks of gestation and the patient gave birth to two female infants at gestational 33 weeks. The pathological examination demonstrated that the DD twin placentas fused in the third trimester.
This report suggests that the splitting of the transferred embryo took place after the blastocyst stage and the popular credo that the timing of embryo division governs the placental configuration of monozygotic twins (MZT) must be re-examined as to its veracity.
报告首例在激素补充周期中进行单个玻璃化冷冻-解冻囊胚移植后，怀上同卵双绒毛膜双羊膜（DD）双胞胎的病例。
患者为 39 岁输卵管性不孕女性。在与丈夫的精子受精后，共获得 6 个卵母细胞，其中 3 个囊胚被玻璃化冷冻。2 个月后，在黄体期第 5 天进行孕激素补充后，解冻了一枚单个囊胚。妊娠 7 周时，超声检查显示两个妊娠囊和具有“lambda”征的胎儿，患者在妊娠 33 周时分娩了两名女婴。病理检查显示 DD 双胎胎盘在妊娠晚期融合。
该报告表明，胚胎的分裂发生在囊胚阶段之后，因此必须重新审视胚胎分裂时间决定单卵双胞胎（MZT）胎盘构型的流行观点的真实性。
