Department of Medical Oncology, Dr BRA Institute Rotary Cancer Hospital, and All India Institute of Medical Sciences, New Delhi 110 029, India.
Indian Pediatr. 2011 Dec;48(12):971-3.
In the recent pandemic of H1N1 infection, pediatric patients with haematological malignancies were considered high risk for severe illness. There is paucity of data regarding course of H1N1 infection in this subgroup. We describe H1N1 infection in 3 children with acute leukemia. All three patients presented with neutropenic fever; 2 had probable fungal pneumonia based on chest imaging and galactomanan estimation. Diagnosis of H1N1 infection was delayed in all 3 patients as it was not suspected initially. One patient died despite treatment. H1NI infection may coexist with other infections in febrile neutropenia.
在最近的 H1N1 感染大流行中，患有血液系统恶性肿瘤的儿科患者被认为有患重病的高风险。关于这亚组人群中 H1N1 感染的病程数据很少。我们描述了 3 例急性白血病患儿的 H1N1 感染情况。所有 3 例患者均表现为中性粒细胞减少性发热；2 例患者基于胸部影像学和半乳甘露聚糖检测，疑似真菌性肺炎。由于最初未怀疑，所有 3 例患者的 H1N1 感染诊断均被延迟。尽管进行了治疗，但 1 例患者还是死亡。在中性粒细胞减少性发热中，H1NI 感染可能与其他感染同时存在。
