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益生菌对急性腹泻婴幼儿粪便特征和血清细胞因子动态变化的短期影响。

Short-term effect of prebiotics administration on stool characteristics and serum cytokines dynamics in very young children with acute diarrhea.

机构信息

Unit of Clinical Nutrition, Tel Aviv Sourasky Medical Center, Sackler Faulty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Nutrients. 2010 Jul;2(7):683-92. doi: 10.3390/nu2070683. Epub 2010 Jun 30.

DOI:10.3390/nu2070683
PMID:22254048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3257680/
Abstract

We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course.

摘要

我们研究了长链果聚糖、半乳寡糖和酸性寡糖混合物对 104 名急性腹泻补充和未补充（9-24 个月龄）受试者粪便数量和稠度以及免疫系统生物标志物的影响。测定了白细胞介素-1 (IL-1)、IL-1 受体拮抗剂 (IL-1RA)、IL-6、IL-8、IL-10、TNF-α 和可溶性白细胞介素-2 受体 (sIL-2R)细胞因子水平。补充组粪便数量减少，粪便稠度增加，但临床相关性不大。唯一显著的变化是补充组 TNF-α 水平降低。在急性腹泻发作期间补充益生元并未影响临床病程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a66c/3257680/d87f9cfbc847/nutrients-02-00683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a66c/3257680/769c0b9f7bdc/nutrients-02-00683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a66c/3257680/cd735479b614/nutrients-02-00683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a66c/3257680/d87f9cfbc847/nutrients-02-00683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a66c/3257680/769c0b9f7bdc/nutrients-02-00683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a66c/3257680/cd735479b614/nutrients-02-00683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a66c/3257680/d87f9cfbc847/nutrients-02-00683-g003.jpg

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本文引用的文献

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Perspectives on the role of the human gut microbiota and its modulation by pro- and prebiotics.探讨人类肠道微生物群及其通过益生菌和益生元调节的作用。
Nutr Res Rev. 2000 Dec;13(2):229-54. doi: 10.1079/095442200108729089.
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Structural and functional aspects of prebiotics used in infant nutrition.用于婴儿营养的益生元的结构和功能方面。
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Immune-modulatory effects and potential working mechanisms of orally applied nondigestible carbohydrates.口服难消化碳水化合物的免疫调节作用及潜在作用机制
Crit Rev Immunol. 2007;27(2):97-140. doi: 10.1615/critrevimmunol.v27.i2.10.
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Dietary supplementation of neutral and acidic oligosaccharides enhances Th1-dependent vaccination responses in mice.在饮食中补充中性和酸性低聚糖可增强小鼠中依赖Th1的疫苗接种反应。
Pediatr Allergy Immunol. 2007 Jun;18(4):304-12. doi: 10.1111/j.1399-3038.2007.00515.x.
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Probiotics for the prevention of pediatric antibiotic-associated diarrhea.益生菌预防儿童抗生素相关性腹泻
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Probiotics and prebiotics: effects on diarrhea.益生菌与益生元：对腹泻的影响
J Nutr. 2007 Mar;137(3 Suppl 2):803S-11S. doi: 10.1093/jn/137.3.803S.
7
Probiotics as functional food in the treatment of diarrhea.益生菌作为治疗腹泻的功能性食品。
Curr Opin Clin Nutr Metab Care. 2006 Nov;9(6):717-21. doi: 10.1097/01.mco.0000247477.02650.51.
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Clinical efficacy of probiotics: review of the evidence with focus on children.益生菌的临床疗效：聚焦儿童的证据综述
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A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age.益生元低聚糖混合物可降低六个月大婴儿患特应性皮炎的几率。
Arch Dis Child. 2006 Oct;91(10):814-9. doi: 10.1136/adc.2006.098251. Epub 2006 Jul 27.
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Effect of a milk formula with prebiotics on the intestinal microbiota of infants after an antibiotic treatment.含益生元的奶粉对接受抗生素治疗后婴儿肠道微生物群的影响。
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