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共轭亚油酸的抗肥胖作用机制。

Antiobesity mechanisms of action of conjugated linoleic acid.

机构信息

Department of Nutrition, University of North Carolina Greensboro, PO Box 26170, Greensboro, NC 27402-6170, USA.

出版信息

J Nutr Biochem. 2010 Mar;21(3):171-9. doi: 10.1016/j.jnutbio.2009.08.003. Epub 2009 Dec 1.

DOI:10.1016/j.jnutbio.2009.08.003
PMID:19954947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2826589/
Abstract

Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.

摘要

共轭亚油酸（CLA）是一种存在于牛肉、乳制品和膳食补充剂中的脂肪酸家族，它可以减少几种肥胖动物模型和一些人体研究中的肥胖。然而，CLA 的异构体特异性抗肥胖作用机制尚不清楚，其在人类中的应用存在争议。本综述将总结文献中关于 CLA 减少肥胖的潜在机制的体内和体外研究结果，包括其对（a）能量代谢、（b）脂肪生成、（c）炎症、（d）脂质代谢和（e）细胞凋亡的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/577970119b6c/nihms146056f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/fb1219a26b7a/nihms146056f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/3b6d0840b08c/nihms146056f2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/3b5119b7d733/nihms146056f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/4b30493632dc/nihms146056f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/328d24fd6d62/nihms146056f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/577970119b6c/nihms146056f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/fb1219a26b7a/nihms146056f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/3b6d0840b08c/nihms146056f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/ade291c15666/nihms146056f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/3b5119b7d733/nihms146056f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/4b30493632dc/nihms146056f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/328d24fd6d62/nihms146056f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e2/2826589/577970119b6c/nihms146056f7.jpg

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本文引用的文献

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A multi-gene analysis strategy identifies metabolic pathways targeted by trans-10, cis-12-conjugated linoleic acid in the liver of hamsters.一种多基因分析策略鉴定出了反式-10，顺式-12-共轭亚油酸在仓鼠肝脏中靶向的代谢途径。
Br J Nutr. 2009 Aug;102(4):537-45. doi: 10.1017/S0007114509231734. Epub 2009 Feb 16.
2
Effects of dietary conjugated linoleic acid at high-fat levels on triacylglycerol regulation in mice.高脂水平膳食共轭亚油酸对小鼠甘油三酯调节的影响。
Nutrition. 2009 Apr;25(4):445-52. doi: 10.1016/j.nut.2008.10.015. Epub 2008 Dec 16.
3
Conjugated linoleic acid prevents growth attenuation induced by corticosteroid administration and increases bone mineral content in young rats.共轭亚油酸可预防皮质类固醇给药引起的生长迟缓，并增加幼鼠的骨矿物质含量。
Appl Physiol Nutr Metab. 2008 Dec;33(6):1096-104. doi: 10.1139/H08-094.
4
Dietary fat concentration influences the effects of trans-10, cis-12 conjugated linoleic acid on temporal patterns of energy intake and hypothalamic expression of appetite-controlling genes in mice.膳食脂肪浓度会影响反式-10，顺式-12共轭亚油酸对小鼠能量摄入时间模式及食欲控制基因下丘脑表达的影响。
J Nutr. 2009 Jan;139(1):145-51. doi: 10.3945/jn.108.093849. Epub 2008 Dec 3.
5
Regulation of osteoblast and adipocyte differentiation from human mesenchymal stem cells by conjugated linoleic acid.共轭亚油酸对人骨髓间充质干细胞向成骨细胞和脂肪细胞分化的调控作用。
J Nutr Biochem. 2009 Dec;20(12):956-64. doi: 10.1016/j.jnutbio.2008.08.008. Epub 2008 Nov 18.
6
Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high-fat diets.膳食共轭亚油酸异构体对高碳水化合物和高脂肪饮食仓鼠脂质代谢的影响。
Br J Nutr. 2009 Jun;101(11):1630-8. doi: 10.1017/S0007114508118785. Epub 2008 Nov 5.
7
Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis.全基因组范围内PPARγ:RXR和RNA聚合酶II占据情况分析揭示脂肪生成过程中不同代谢途径的时间性激活以及RXR二聚体组成的变化。
Genes Dev. 2008 Nov 1;22(21):2953-67. doi: 10.1101/gad.501108.
8
Effects of trans10cis12CLA-induced insulin resistance on retinol-binding protein 4 concentrations in abdominally obese men.反式10顺式12共轭亚油酸诱导的胰岛素抵抗对腹型肥胖男性视黄醇结合蛋白4浓度的影响。
Diabetes Res Clin Pract. 2008 Dec;82(3):e23-4. doi: 10.1016/j.diabres.2008.09.034. Epub 2008 Nov 5.
9
Arachidonic acid prevents fatty liver induced by conjugated linoleic acid in mice.花生四烯酸可预防共轭亚油酸诱导的小鼠脂肪肝。
Br J Nutr. 2009 May;101(10):1558-63. doi: 10.1017/S0007114508091253. Epub 2008 Oct 24.
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Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol.白藜芦醇可减轻共轭亚油酸介导的人体脂肪细胞炎症和胰岛素抵抗。
J Lipid Res. 2009 Feb;50(2):225-32. doi: 10.1194/jlr.M800258-JLR200. Epub 2008 Sep 5.