Department of Nutritional Sciences and Obstetrics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Appl Physiol Nutr Metab. 2009 Oct;34(5):975-8. doi: 10.1139/H09-080.
Treatment of laboratory animals with a 50:50 mixture of c9,t11 and t10,c12 conjugated linoleic acid (CLA) results in fat loss and, to a smaller degree, fat-free mass (FFM) gain. In a previous meta-analysis, we found that CLA produced a fat loss, but that humans were not as responsive as mice. We performed a similar meta-analysis in the same 18 studies to test whether CLA increased FFM. Only placebo-controlled trials that measured body composition were included. We found that FFM increased during CLA treatment (0.3 +/- 0.7 kg; p = 0.05), but that the change did not display an effect of length of treatment (0.001 +/- 0.005 kg.week(-1); p = 0.8), or an effect of dosage (0.1 +/- 0.1 kg.g CLA(-1).day(-1); p = 0.3). We conclude that FFM does increase in humans during CLA treatment, but the onset of the increase is rapid and the total increase is small (<1%).
用 9:11 和 10:12 共轭亚油酸（CLA）的 50:50 混合物对实验动物进行治疗会导致脂肪减少，并且在较小程度上导致无脂肪质量（FFM）增加。在之前的荟萃分析中，我们发现 CLA 可导致脂肪减少，但人类的反应不如老鼠强烈。我们在相同的 18 项研究中进行了类似的荟萃分析，以测试 CLA 是否增加 FFM。只包括了对照安慰剂的测量身体成分的试验。我们发现，在 CLA 治疗期间 FFM 增加（0.3 +/- 0.7 千克；p = 0.05），但治疗时间的变化并没有显示出效果（0.001 +/- 0.005 千克.周（-1）；p = 0.8），或者剂量的效果（0.1 +/- 0.1 千克.g CLA（-1）.天（-1）；p = 0.3）。我们的结论是，在 CLA 治疗期间，FFM 在人体中确实会增加，但增加的起始速度很快，总增加量很小（<1%）。
