Pawitan Jeanne Adiwinata
Department of Histology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
Anat Cell Biol. 2011 Dec;44(4):256-64. doi: 10.5115/acb.2011.44.4.256. Epub 2011 Dec 30.
The hallmark of Parkinson's disease is on-going degeneration of dopaminergic neurons in the substantia nigra, which may be due to various etiologies. Various approaches to alleviate symptoms are available, such as life-long pharmacological intervention, deep brain stimulation, and transplantation of dopaminergic neuron-containing fetal tissue. However, each of these approaches has a disadvantage. Several studies have shown that various kinds of stem cells, induced pluripotent stem cells, and other cells can differentiate into dopaminergic neurons and may be promising for treating Parkinson's disease in the future. Therefore, this review addresses those cells in terms of their prospects in cell therapy for Parkinson's disease. In addition, the need for safety and efficacy studies, various cell delivery modes and sites, and possible side effects will be discussed.
帕金森病的标志是黑质中多巴胺能神经元持续退化，这可能由多种病因引起。有多种缓解症状的方法，如终身药物干预、深部脑刺激以及移植含多巴胺能神经元的胎儿组织。然而，这些方法每种都有缺点。多项研究表明，各种干细胞、诱导多能干细胞及其他细胞可分化为多巴胺能神经元，未来可能有望用于治疗帕金森病。因此，本综述从这些细胞在帕金森病细胞治疗中的前景方面进行阐述。此外，还将讨论安全性和有效性研究的必要性、各种细胞递送方式和部位以及可能的副作用。
