Petrov I Y, Petrov Y, Prough D S, Deyo D J, Cicenaite I, Esenaliev R O
Laboratory for Optical Sensing and Monitoring, Center for Biomedical Engineering, The University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1156, USA.
Biomed Opt Express. 2012 Jan 1;3(1):125-36. doi: 10.1364/BOE.3.000125. Epub 2011 Dec 14.
There is strong clinical evidence that controlling cerebral venous oxygenation (oxyhemoglobin saturation) is critically important for patients with severe traumatic brain injury as well as for patients undergoing cardiac surgery. However, the only available method for cerebral venous blood oxygenation monitoring is invasive and requires catheterization of the internal jugular vein. We designed and built a novel optoacoustic monitor of cerebral venous oxygenation as measured in the superior sagittal sinus (SSS), the large midline cerebral vein. To the best of our knowledge, optical monitoring of cerebral venous blood oxygenation through overlying extracerebral blood is reported for the first time in this paper. The system was capable of detecting SSS signals in vivo at 700, 800, and 1064 nm through the thick (5-6 mm) sheep skull containing the circulating blood. The high (submillimeter) in-depth resolution of the system provided identification of the SSS peaks in the optoacoustic signals. The SSS peak amplitude closely followed the actual SSS blood oxygenation measured invasively using catheterization, blood sampling, and "gold standard" CO-Oximetry. Our data indicate the system may provide accurate measurement of the SSS blood oxygenation in patients with extracerebral blood over the SSS.
有强有力的临床证据表明，控制脑静脉氧合（氧合血红蛋白饱和度）对于重型颅脑损伤患者以及接受心脏手术的患者至关重要。然而，目前唯一可用于监测脑静脉血氧合的方法具有侵入性，需要对颈内静脉进行插管。我们设计并构建了一种新型的光声监测仪，用于测量上矢状窦（SSS，大脑中线的大静脉）中的脑静脉氧合。据我们所知，本文首次报道了通过覆盖的脑外血液对脑静脉血氧合进行光学监测。该系统能够通过含有循环血液的厚（5 - 6毫米）羊颅骨，在体内700、800和1064纳米处检测到上矢状窦信号。该系统高（亚毫米）的深度分辨率能够识别光声信号中的上矢状窦峰值。上矢状窦峰值幅度与使用插管、采血和“金标准”共血氧测定法侵入性测量的实际脑静脉血氧合密切相关。我们的数据表明，该系统可能为上矢状窦上方存在脑外血液的患者提供准确的上矢状窦血氧合测量。
