Hoyer Dirk, Nowack Samuel, Schneider Uwe
Biomagnetic Center, Hans Berger Department for Neurology, University Hospital, Friedrich Schiller University, Jena, Germany.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:1451-4. doi: 10.1109/IEMBS.2011.6090336.
The increasing functional integrity of the organism during fetal maturation is connected with increasing complex internal coordination mediated by the autonomic nervous system. We hypothesize that time scales of complex and dynamic inter-dependencies over more than one heart beat interval reflect the increasing complex adjustments within the fetal organism during its prenatal development. We investigated multi-scale complexity and time irreversibility from equidistantly resampled heart rate time series of 73 fetal magnetocardiographic recordings over the third trimester. We found scale dependent changes in complexity and time irreversibility. The functions obtained from equidistantly resampled heart rate time series showed qualitatively similar curves compared to those obtained from heart beat intervals series previously reported. Time scales of fetal heart rate characteristics may provide novel information for the identification of developmental disorders in prenatal diagnosis.
在胎儿成熟过程中，机体功能完整性的增强与自主神经系统介导的日益复杂的内部协调相关。我们假设，超过一个心跳间期的复杂动态相互依赖的时间尺度反映了胎儿在产前发育过程中机体内部日益复杂的调节。我们研究了来自孕晚期73例胎儿磁心动图记录的等距重采样心率时间序列的多尺度复杂性和时间不可逆性。我们发现了复杂性和时间不可逆性的尺度依赖性变化。与先前报道的心跳间期序列所获得的曲线相比，等距重采样心率时间序列所获得的函数显示出定性相似的曲线。胎儿心率特征的时间尺度可能为产前诊断中发育障碍的识别提供新的信息。
