Mills R P, Albizzati C, Todd A S
Department of Otolaryngology and Haematology, University of Dundee, Ninewells Hospital, UK.
Clin Otolaryngol Allied Sci. 1990 Aug;15(4):315-9. doi: 10.1111/j.1365-2273.1990.tb00475.x.
The relative ease with which different ear drops pass through grommets of different designs has been investigated using a laboratory model. The viscosities of the various ear drop preparations tested have also been determined. There is a considerable variation in the volume of ear drops required to penetrate ventilation tubes. Their ease of passage is determined by the size of the tube and is probably also related to the ease with which a preparation wets the surface of the grommet. There is no relationship between ease of penetration and viscosity. The penetration of ear drops through grommets during episodes of aural discharge was studied in vivo. Penetration into the middle ear was observed only when the drops were introduced using the displacement technique. It was more readily achieved when the grommet lumen was free of discharge.
使用实验室模型研究了不同设计的滴耳剂通过不同类型鼓膜通气管的相对难易程度。还测定了所测试的各种滴耳剂制剂的粘度。穿透通气管所需的滴耳剂体积存在相当大的差异。其通过的难易程度取决于通气管的大小，可能还与制剂润湿鼓膜通气管表面的难易程度有关。穿透难易程度与粘度之间没有关系。在体内研究了耳漏发作期间滴耳剂通过鼓膜通气管的情况。只有当使用置换技术引入滴耳剂时，才观察到其进入中耳。当鼓膜通气管管腔无分泌物时，更容易实现。
