长期植入猫皮层的穿透性微电极的电学性能
Electrical performance of penetrating microelectrodes chronically implanted in cat cortex.
作者信息
Kane Sheryl R, Cogan Stuart F, Ehrlich Julia, Plante Timothy D, McCreery Douglas B
机构信息
EIC Laboratories, Inc Norwood, MA 02062, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:5416-9. doi: 10.1109/IEMBS.2011.6091339.
Abstract
Penetrating multielectrode arrays with electrode coatings of sputtered iridium oxide (SIROF) have been implanted chronically in cat cortex for periods over 300 days. The ability of these electrodes to inject charge at levels above expected thresholds for neural excitation has been examined in vivo by measurements of voltage transients in response to current-controlled, cathodal stimulation pulsing. The effect of current pulse width from 150 μs to 500 μs and voltage biasing of the electrodes in the interpulse period at two levels, 0.0 V and 0.6 V vs. Ag|AgCl, were also investigated. The results of in vivo characterization of the electrodes by open-circuit potential measurements, cyclic voltammetry and impedance spectroscopy are also reported.
摘要
带有溅射氧化铱电极涂层（SIROF）的穿透式多电极阵列已长期植入猫的皮层中达300多天。通过测量响应电流控制的阴极刺激脉冲的电压瞬变，在体内研究了这些电极在高于神经兴奋预期阈值的水平注入电荷的能力。还研究了电流脉冲宽度从150微秒到500微秒以及在两个电平（相对于Ag|AgCl为0.0 V和0.6 V）的脉冲间期对电极进行电压偏置的影响。还报告了通过开路电位测量、循环伏安法和阻抗谱对电极进行体内表征的结果。
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