Lee Won Hee, Deng Zhi-De, Laine Andrew F, Lisanby Sarah H, Peterchev Angel V
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:5473-6. doi: 10.1109/IEMBS.2011.6091396.
The goal of this study is to investigate the influence of white matter conductivity anisotropy on the electric field strength induced by electroconvulsive therapy (ECT). We created an anatomically-realistic finite element human head model incorporating tissue heterogeneity and white matter conductivity anisotropy using structural magnetic resonance imaging (MRI) and diffusion tensor MRI data. The electric field spatial distributions of three conventional ECT electrode placements (bilateral, bifrontal, and right unilateral) and an experimental electrode configuration, focal electrically administered seizure therapy (FEAST), were computed. A quantitative comparison of the electric field strength was subsequently performed in specific brain regions of interest thought to be associated with side effects of ECT (e.g., hippocampus and in-sula). The results show that neglecting white matter conductivity anisotropy yields a difference up to 19%, 25% and 34% in electric field strength in the whole brain, hippocampus, and insula, respectively. This study suggests that white matter conductivity anisotropy should be taken into account in ECT electric field models.
本研究的目的是调查白质电导率各向异性对电惊厥治疗（ECT）诱导的电场强度的影响。我们使用结构磁共振成像（MRI）和扩散张量MRI数据创建了一个包含组织异质性和白质电导率各向异性的解剖学真实有限元人体头部模型。计算了三种传统ECT电极放置方式（双侧、双额和右侧单侧）以及一种实验性电极配置——局灶性电惊厥治疗（FEAST）的电场空间分布。随后在被认为与ECT副作用相关的特定感兴趣脑区（如海马体和岛叶）对电场强度进行了定量比较。结果表明，忽略白质电导率各向异性会使全脑、海马体和岛叶的电场强度分别产生高达19%、25%和34%的差异。本研究表明，在ECT电场模型中应考虑白质电导率各向异性。
