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经颅电刺激和磁刺激剂量基础：定义、选择和报告实践。

Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices.

机构信息

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina 27710, USA.

出版信息

Brain Stimul. 2012 Oct;5(4):435-53. doi: 10.1016/j.brs.2011.10.001. Epub 2011 Nov 1.

DOI:10.1016/j.brs.2011.10.001
PMID:22305345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3346863/
Abstract

BACKGROUND

The growing use of transcranial electric and magnetic (EM) brain stimulation in basic research and in clinical applications necessitates a clear understanding of what constitutes the dose of EM stimulation and how it should be reported.

METHODS

This paper provides fundamental definitions and principles for reporting of dose that encompass any transcranial EM brain stimulation protocol.

RESULTS

The biologic effects of EM stimulation are mediated through an electromagnetic field injected (via electric stimulation) or induced (via magnetic stimulation) in the body. Therefore, transcranial EM stimulation dose ought to be defined by all parameters of the stimulation device that affect the electromagnetic field generated in the body, including the stimulation electrode or coil configuration parameters: shape, size, position, and electrical properties, as well as the electrode or coil current (or voltage) waveform parameters: pulse shape, amplitude, width, polarity, and repetition frequency; duration of and interval between bursts or trains of pulses; total number of pulses; and interval between stimulation sessions and total number of sessions. Knowledge of the electromagnetic field generated in the body may not be sufficient but is necessary to understand the biologic effects of EM stimulation.

CONCLUSIONS

We believe that reporting of EM stimulation dose should be guided by the principle of reproducibility: sufficient information about the stimulation parameters should be provided so that the dose can be replicated.

摘要

背景

经颅电刺激和磁刺激（EM）在基础研究和临床应用中的应用越来越广泛，这就需要清楚地了解 EM 刺激的剂量构成以及应如何报告。

方法

本文提供了报告剂量的基本定义和原则，涵盖了任何经颅 EM 脑刺激方案。

结果

EM 刺激的生物学效应是通过在体内注入（通过电刺激）或感应（通过磁刺激）的电磁场介导的。因此，经颅 EM 刺激剂量应通过影响体内产生的电磁场的所有刺激设备参数来定义，包括刺激电极或线圈的配置参数：形状、大小、位置和电特性，以及电极或线圈电流（或电压）波形参数：脉冲形状、幅度、宽度、极性和重复频率；脉冲的持续时间和脉冲之间的间隔、爆发或脉冲串的总脉冲数；以及刺激疗程之间的间隔和总疗程数。了解体内产生的电磁场可能还不够，但对于理解 EM 刺激的生物学效应是必要的。

结论

我们认为，EM 刺激剂量的报告应遵循可重复性原则：应提供足够的刺激参数信息，以便复制剂量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/49da78e9d579/nihms331673f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/6f1229c7fe4e/nihms331673f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/272cb2b936e4/nihms331673f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/7e148bd76c94/nihms331673f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/49da78e9d579/nihms331673f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/6f1229c7fe4e/nihms331673f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/272cb2b936e4/nihms331673f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/7e148bd76c94/nihms331673f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a6/3346863/49da78e9d579/nihms331673f4.jpg

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