Koda Ren, Watarai Nobuyuki, Nakamoto Ryusuke, Ohta Taku, Masuda Kohji, Miyamoto Yoshitaka, Chiba Toshio
Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:5589-92. doi: 10.1109/IEMBS.2011.6091352.
We have previously reported our attempts to control microbubbles (microcapsules) behavior in flow by primary Bjerknes force to increase the local concentration of the bubbles at a diseased part. However, there was a limitation in efficiency to propel bubbles of μm-order size. Thus we consider that forming aggregates of bubbles is effective to be propelled before entering into an ultrasound field by making use of secondary Bjerknes force under continuous ultrasound exposure. In this study, we observed the phenomena of aggregates formation by confirming variation of diameter and density of aggregates under various conditions of ultrasound exposure. Then we elucidated frequency dependence of the size of aggregates of micro-bubbles.
我们之前曾报道过，我们试图通过一次 Bjerknes 力来控制流动中的微泡（微胶囊）行为，以提高患病部位气泡的局部浓度。然而，推动微米级尺寸气泡的效率存在局限性。因此，我们认为在连续超声照射下，利用二次 Bjerknes 力使气泡形成聚集体，在进入超声场之前被推动是有效的。在本研究中，我们通过确认在各种超声照射条件下聚集体直径和密度的变化，观察了聚集体形成的现象。然后我们阐明了微泡聚集体尺寸的频率依赖性。
