Ahlberg J, Angelin B, Einarsson K, Hellström K, Leijd B
Dig Dis Sci. 1979 Jun;24(6):459-64. doi: 10.1007/BF01299828.
An analysis of the occurrence of gallbladder disease (ie, cholelithiasis, cholecystitis, cholecystectomy) in 210 consecutive patients with primary hyperlipoproteinemia showed that the prevalence of gallbladder disease was 8%, 18%, and 42% in males with type IIa, IIb, and IV hyperlipoproteinemia, and 22%, 48%, and 72% in the corresponding groups of females. The 40-59-year-old patients were compared to three necropsy series from Malmö, Sweden. The occurrence of gallbladder disease was within normal limits in type IIa and abnormally high in type IV hyperlipoproteinemia. There were no differences with regard to age, body weight, glucose intolerance, or ischemic heart disease between type IV patients with and without GBD. It is suggested that certain forms of disturbances of lipoprotein metabolism are associated with an increased risk for development of gallbladder disease.
对连续210例原发性高脂血症患者的胆囊疾病（即胆石症、胆囊炎、胆囊切除术）发生情况进行分析，结果显示，IIa型、IIb型和IV型高脂血症男性患者的胆囊疾病患病率分别为8%、18%和42%，相应女性组分别为22%、48%和72%。将40至59岁的患者与瑞典马尔默的三个尸检系列进行比较。IIa型患者的胆囊疾病发生率在正常范围内，IV型高脂血症患者的发生率异常高。有胆囊疾病和无胆囊疾病的IV型患者在年龄、体重、葡萄糖耐量或缺血性心脏病方面无差异。提示某些形式的脂蛋白代谢紊乱与胆囊疾病发生风险增加有关。
