[New approaches to the evaluation of the cholesterol content of plasma lipoprotein fractions in normo- and hyperlipoproteinemias].

The examination of 1073 males ranging in age from 40 to 59 living in Moscow and Leningrad, and of 146 patients with ischemic heart disease showed a decrease in the alpha-lipoprotein cholesterol level and an increase in the cholesterol content of atherogenic fractions (beta- and pre-beta-lipoproteins) in individuals with ischemic heart disease in the absence of hyperlipoproteinemia (HLP). In combination of ischemic heart disease with hyperlipoproteinemia these changes are pronounced to a larger degree. From the analysis of the results of the studies it is suggested that the coefficient (see article) is determined to reveal disorders in lipoprotein metabolism particularly in the absence of hyperlipoproteinemia. This coefficient is significantly higher in individuals with ischemic heart disease and no hyperlipoproteinemia than in healthy males of the same age group; its value is highest in ischemic disease with hyperlipoproteinemia.