von Zerssen D, León C A, Möller H J, Wittchen H U, Pfister H, Sartorius N
Max Planck Institute of Psychiatry, Munich, FRG.
Compr Psychiatry. 1990 Sep-Oct;31(5):398-408. doi: 10.1016/0010-440x(90)90024-m.
This study was conducted in order to test the hypothesis derived from the International Pilot Study of Schizophrenia (IPSS) that the existence of extended families in developing countries contributes to the more favorable course and outcome of schizophrenia in these countries in comparison with industrial countries. For this purpose, we compared data from the 5- and 10-year follow-up obtained within the IPSS at Cali, Colombia with data from two 5- to 8-year follow-up studies of former schizophrenic inpatients of the Max Planck Institute of Psychiatry (MPIP) in Munich, FRG. Although, in Cali, schizophrenics are hospitalized and treated with drugs only during acute episodes of the psychosis and no facilities exist for long-term treatment, the psychopathological outcome was, on the whole, not worse than in Munich. Furthermore, the duration of hospitalization during the follow-up period was much lower at Cali and a significantly lower number of Colombian than of German patients was not separated from their families. However, contrary to the hypothesis, family size did not predict course and outcome at both centers.
开展这项研究是为了验证源自精神分裂症国际试点研究（IPSS）的假设，即与工业化国家相比，发展中国家大家庭的存在有助于精神分裂症在这些国家有更有利的病程和转归。为此，我们将哥伦比亚卡利的IPSS中5年和10年随访数据与联邦德国慕尼黑马克斯·普朗克精神病学研究所（MPIP）对既往精神分裂症住院患者进行的两项5至8年随访研究数据进行了比较。尽管在卡利，精神分裂症患者仅在精神病急性发作期间住院并接受药物治疗，且不存在长期治疗设施，但总体而言，精神病理学转归并不比慕尼黑差。此外，随访期间卡利的住院时间要短得多，与德国患者相比，与家人分离的哥伦比亚患者数量要少得多。然而，与假设相反，家庭规模并不能预测两个中心的病程和转归。
