Department of Clinical Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, Duarte, CA, USA.
Pancreas. 2012 Aug;41(6):863-8. doi: 10.1097/MPA.0b013e31823c947c.
The association of hypovitaminosis D with type 2 diabetes is well recognized. Although hypovitaminosis D is associated with insulin resistance, there is much less information about its impact on β-cell function in humans.
We enrolled 150 healthy, glucose-tolerant subjects for the assessment of β-cell function (acute insulin response) and insulin sensitivity index (ISI) using a hyperglycemic clamp. Adjusted β-cell function (ABCF) was defined as the product of acute insulin response and ISI. The relations of plasma 25-hydroxyvitamin D [25(OH)D] level with insulin sensitivity and ABCF were examined.
Plasma 25(OH)D levels were positively associated with ABCF (P = 0.00004) and ISI (P < 0.00001). The associations remained significant after adjustment for age, sex, body mass index, physical activity, ethnicity, and season of study.
Plasma 25(OH)D levels are positively association with both β-cell function and insulin sensitivity. Our observations suggest the roles of vitamin D deficiency in the dual defect of type 2 diabetes.
维生素 D 缺乏与 2 型糖尿病之间的关联已得到广泛认可。尽管维生素 D 缺乏与胰岛素抵抗有关，但关于其对人类β细胞功能的影响的信息却很少。
我们招募了 150 名健康、糖耐量正常的受试者，使用高血糖钳夹技术评估β细胞功能（急性胰岛素反应）和胰岛素敏感指数（ISI）。调整后的β细胞功能（ABCF）定义为急性胰岛素反应和 ISI 的乘积。检测血浆 25-羟维生素 D [25(OH)D]水平与胰岛素敏感性和 ABCF 的关系。
血浆 25(OH)D 水平与 ABCF（P = 0.00004）和 ISI（P < 0.00001）呈正相关。在校正年龄、性别、体重指数、体力活动、种族和研究季节后，这些关联仍然显著。
血浆 25(OH)D 水平与β细胞功能和胰岛素敏感性均呈正相关。我们的观察结果表明，维生素 D 缺乏在 2 型糖尿病的双重缺陷中起作用。
