Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Int J Mol Sci. 2023 Feb 13;24(4):3751. doi: 10.3390/ijms24043751.
Vitamin D is a hormone involved in many physiological processes. Its active form, 1,25(OH)D, modulates serum calcium-phosphate homeostasis and skeletal homeostasis. A growing body of evidence has demonstrated the renoprotective effects of vitamin D. Vitamin D modulates endothelial function, is associated with podocyte preservation, regulates the renin-angiotensin-aldosterone system, and has anti-inflammatory effects. Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease worldwide. There are numerous studies supporting vitamin D as a renoprotector, potentially delaying the onset of DKD. This review summarizes the findings of current research on vitamin D and its role in DKD.
维生素 D 是一种参与多种生理过程的激素。其活性形式 1,25(OH)D 调节血清钙磷稳态和骨骼稳态。越来越多的证据表明维生素 D 具有肾保护作用。维生素 D 调节内皮功能，与足细胞保护有关，调节肾素-血管紧张素-醛固酮系统，具有抗炎作用。糖尿病肾病 (DKD) 是全球导致终末期肾病的主要原因。有许多研究支持维生素 D 作为一种肾保护剂，可以潜在地延缓 DKD 的发生。本综述总结了目前关于维生素 D 及其在 DKD 中作用的研究结果。
