Bae Gyu-Seong, Choi Seung-Won, Youm Jin-Young, Kim Seon-Hwan
Department of Neurosurgery, School of Medicine, Chungnam National University, Daejeon, Korea.
J Korean Neurosurg Soc. 2011 Nov;50(5):468-71. doi: 10.3340/jkns.2011.50.5.468. Epub 2011 Nov 30.
Mesenchymal chondrosarcomas are rare malignant tumors of the bone and soft tissue. Spinal mesenchymal chondrosarcomas are even rarer and, to the best of our knowledge those that are concomitantly located in the intradural and extradural regions, have never been reported. We report a case of a 25-year-old man with back pain and bilateral progressive weakness of the lower extremities. Magnetic resonance imaging revealed a markedly enhanced dumbbell-shaped mass at the T7 level. The lesion was intradurally located at the left side of the spinal cord, and extended extradurally to the extraforminal space through the T7-8 intervertebral foramen. The tumor was completely excised through a posterior approach. Microscopic examination and immunohistochemical studies confirmed mesenchymal chondrosarcoma. Postoperative radiation therapy and chemotherapy were also performed to prevent local recurrence and metastasis. The patient has been symptom-free for two years after surgery. Herein, we reviewed and discussed the clinical characteristics, treatments, and outcomes of primary intraspinal mesenchymal chondrosarcomas in the literature.
间叶性软骨肉瘤是一种罕见的骨与软组织恶性肿瘤。脊柱间叶性软骨肉瘤更为罕见，据我们所知，同时位于硬膜内和硬膜外区域的此类肿瘤从未有过报道。我们报告一例25岁男性患者，有背痛及双下肢进行性无力症状。磁共振成像显示T7水平有一明显强化的哑铃形肿块。病变位于脊髓左侧硬膜内，通过T7 - 8椎间孔硬膜外扩展至椎间孔外间隙。通过后路手术将肿瘤完全切除。显微镜检查和免疫组化研究证实为间叶性软骨肉瘤。术后还进行了放射治疗和化疗以预防局部复发和转移。患者术后两年无症状。在此，我们回顾并讨论了文献中原发性脊柱内间叶性软骨肉瘤的临床特征、治疗方法及预后情况。
