Vanderhooft J E, Conrad E U, Anderson P A, Richardson M L, Bruckner J
Department of Orthopaedics, University of Washington, Seattle 98195.
Clin Orthop Relat Res. 1993 Sep(294):90-5.
Known for its resistance to chemotherapy and radiation therapy, chondrosarcoma remains largely a surgically managed tumor predisposed to local recurrence and late distant metastasis. A 42-year-old man with known thoracic chondrosarcoma developed progressive low back pain, lower extremity weakness, and urinary incontinence. Magnetic resonance imaging and computed tomographic myelography demonstrated multiple filling defects throughout the lumbosacral region. Surgical excision of these lesions disclosed intradural, extramedullary drop metastases of the chondrosarcoma. The spread of neoplasms within the dural space is uncommon, accounting for less than 5% of spinal metastases, and has not previously been reported for chondrosarcoma.
软骨肉瘤以其对化疗和放疗的耐药性而闻名,在很大程度上仍是一种以外科手术治疗为主的肿瘤,容易发生局部复发和晚期远处转移。一名患有胸椎软骨肉瘤的42岁男性出现进行性腰痛、下肢无力和尿失禁。磁共振成像和计算机断层脊髓造影显示腰骶部区域有多处充盈缺损。对这些病变进行手术切除后发现为软骨肉瘤的硬脊膜内、髓外播散性转移。肿瘤在硬膜腔内的扩散并不常见,占脊柱转移瘤的比例不到5%,此前尚未有软骨肉瘤发生这种情况的报道。