Rheumatology and Physical Rehabilitation Department, El Ayachi Hospital, Salé, Morocco.
Clin Exp Rheumatol. 2012 Jan-Feb;30(1):106-9. Epub 2012 Mar 7.
The Patient Acceptable Symptom State (PASS) is the value beyond which patients consider themselves well. Our aim was to determine the PASS estimate for patients with AS by assessing pain, disease activity and functional impairment and evaluate whether the PASS is stable over time.
A 4-week prospective study of patients with AS was carried-out. The PASS was estimated at week 2 and 4 for the following patient reported outcomes: global and nocturnal pain measured on a visual analogue scale, disease activity (BASDAI), and functional impairment (BASFI). We used an anchoring method based on patients answering yes or no to, 'is your current condition satisfactory, when you take your general functioning and your current pain into consideration?' The PASS was defined as the 75th percentile of the score for patients who considered their state satisfactory. Pearson's chi square and binary logistic regression were used to analyse the data.
A total of 200 patients were recruited of whom 110 (55%) were in PASS. The PASS estimates were 60 mm for global pain, 40 mm for night pain, 4.0 for BASDAI and 4.3 for BASFI. These PASS values were stable over time for all criteria except for pain. Significant contributors to PASS were low functional impairment ([BASFI]; p<0.001), low pain intensity (p=0.02), intensive physical activity (p=0.004) and high educational level (p=0.01).
A high percentage of Moroccan patients with AS (55%) reported being in PASS. PASS threshold for pain was unexpectedly high, possibly suggesting a high level of patients' tolerance to pain.
患者可接受的症状状态（PASS）是患者自我感觉良好的数值。我们的目的是通过评估疼痛、疾病活动度和功能障碍来确定 AS 患者的 PASS 估计值，并评估 PASS 是否随时间稳定。
对 AS 患者进行了为期 4 周的前瞻性研究。在第 2 周和第 4 周，通过以下患者报告的结果评估 PASS：视觉模拟量表测量的整体和夜间疼痛、疾病活动度（BASDAI）和功能障碍（BASFI）。我们使用一种基于患者回答“考虑到您的一般功能和当前疼痛，您目前的状况是否满意？”的锚定方法。PASS 定义为认为自己状态满意的患者得分的第 75 个百分位数。使用 Pearson 卡方检验和二元逻辑回归分析数据。
共招募了 200 名患者，其中 110 名（55%）处于 PASS 状态。PASS 估计值分别为 60mm 用于整体疼痛，40mm 用于夜间疼痛，4.0 用于 BASDAI 和 4.3 用于 BASFI。除疼痛外，所有标准的 PASS 值均随时间稳定。对 PASS 有重要贡献的因素是低功能障碍（[BASFI]；p<0.001）、低疼痛强度（p=0.02）、剧烈的体力活动（p=0.004）和高教育水平（p=0.01）。
相当比例的摩洛哥 AS 患者（55%）报告处于 PASS 状态。疼痛的 PASS 阈值出人意料地高，这可能表明患者对疼痛的耐受水平较高。
