Eight-year Programme, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Clin Exp Rheumatol. 2012 Jan-Feb;30(1):103-5. Epub 2012 Jan 16.
The immunoreactants detected by direct immunofluorescence (DIF) from the skin of patients with lupus erythematosus (LE) were related to disease subtypes and skin morphology. Male patients presented more frequently with discoid rashes and females with malar rashes. We investigated the differences in immunoreactants in skin lesions between male and female LE patients.
The DIF records of 186 LE patients were reviewed and analysed.
Among 186 patients (133 female and 53 male), 54 had cutaneous LE (CLE) and 132 had systemic LE (SLE). In the CLE group, eight of 33 (24.2%) women were DIF+ versus nine of 21(42.9%) men (p=0.23). In the SLE group, 49 of 100 (49%) women were DIF+ versus 17 of 32 (53.1%) men (p=0.84). The p-value was 0.01 when comparing DIF incidence between female CLE and SLE patients. IgM and complement component 3 (C3) were present in 84.2% and 52.6% of DIF+female patients, respectively, and both were comparable between genders (p>0.05). However, IgG was observed only in eight of 57 female patients, and in 10 of 26 male patients (p=0.02). Among DIF+CLE patients, IgG was detected in none of the eight female versus three of nine male patients.
Detection of immunoreactants in skin had no gender bias in CLE or SLE, but among women, it was probably lower in CLE than SLE. IgM and C3 were the most frequent immunoreactants in skin with no gender disparity, whereas IgG in female patients was lower than in males.
红斑狼疮（LE）患者皮肤直接免疫荧光（DIF）检测到的免疫反应物与疾病亚型和皮肤形态有关。男性患者更常出现盘状皮疹，而女性患者更常出现蝶形皮疹。我们研究了男性和女性 LE 患者皮肤病变中免疫反应物的差异。
回顾分析了 186 例 LE 患者的 DIF 记录。
在 186 例患者（133 例女性和 53 例男性）中，54 例为皮肤红斑狼疮（CLE），132 例为系统性红斑狼疮（SLE）。在 CLE 组中，33 例女性中有 8 例（24.2%）DIF+，21 例男性中有 9 例（42.9%）（p=0.23）。在 SLE 组中，100 例女性中有 49 例（49%）DIF+，32 例男性中有 17 例（53.1%）（p=0.84）。当比较女性 CLE 和 SLE 患者 DIF 发生率时，p 值为 0.01。在 DIF+女性患者中，IgM 和补体成分 3（C3）分别分别为 84.2%和 52.6%，性别之间无差异（p>0.05）。然而，在 57 例女性患者中仅观察到 IgG，在 26 例男性患者中观察到 10 例（p=0.02）。在 DIF+CLE 患者中，8 例女性患者无一例检测到 IgG，而 9 例男性患者中有 3 例检测到 IgG。
在 CLE 或 SLE 中，皮肤免疫反应物的检测没有性别差异，但在女性中，CLE 可能比 SLE 低。IgM 和 C3 是皮肤中最常见的免疫反应物，无性别差异，而女性患者的 IgG 低于男性。
