Banting and Best Department of Medical Research and Department of Molecular Genetics, Donnelly Centre, University of Toronto, 160 College St., Toronto, ON, Canada M5S 3E1.
Bioorg Med Chem. 2012 Mar 15;20(6):1952-60. doi: 10.1016/j.bmc.2011.12.023. Epub 2011 Dec 21.
Chemical-genomic (CG) profiling of bioactive compounds is a powerful approach for drug target identification and mode of action studies. Within the last decade, research focused largely on the development and application of CG approaches in the model yeast Saccharomyces cerevisiae. The success of these methods has sparked interest in transitioning CG profiling to other biological systems to extend clinical and evolutionary relevance. Additionally, CG profiling has proven to enhance drug-synergy screens for developing combinatorial therapies. Herein, we briefly review CG profiling, focusing on emerging cross-species technologies and novel drug-synergy applications, as well as outlining needs within the field.
化学基因组学（CG）分析生物活性化合物是一种用于药物靶标鉴定和作用模式研究的强大方法。在过去的十年中，研究主要集中在模型酵母酿酒酵母中 CG 方法的开发和应用上。这些方法的成功激发了将 CG 分析转向其他生物系统的兴趣，以扩大临床和进化相关性。此外，CG 分析已被证明可以增强用于开发组合疗法的药物协同筛选。本文简要回顾了 CG 分析，重点介绍了新兴的跨物种技术和新的药物协同应用，并概述了该领域的需求。
