Department, Health Protection Agency Colindale, 61 Colindale Ave, London NW9 5EQ, UK.
Emerg Infect Dis. 2012 Jan;18(1):63-70. doi: 10.3201/eid1801.110901.
Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007-2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring.
在英格兰和威尔士，强化的全国侵袭性脑膜炎球菌病监测发现，实验室确诊的 Y 群（MenY）疾病病例从 2007 年的 34 例增加到 2008 年的 44 例和 2009 年的 65 例。对于 2009 年诊断的病例，患者发病时的中位年龄为 60 岁；39%的患者有潜在的医疗条件，19%的患者死亡。2007-2009 年引起侵袭性疾病的 MenY 分离株主要属于 4 个克隆复合体（cc）中的 1 个，cc23（56%的分离株）、cc174（21%）、cc167（11%）和 cc22（8%）。2009 年的增加主要是由于 1655 型（cc23）（2009 年有 22 例，而 2007 年和 2008 年各有 4 例）。cc23 与 lpxL1 突变和年轻年龄组（<25 岁）的脑膜炎有关；cc174 与非脑膜炎有关，特别是老年年龄组（>65 岁）的肺炎。MenY 疾病的增加需要仔细进行流行病学和分子监测。
