组织化学作为形态分析的工具：历史回顾。

Histochemistry as a tool in morphological analysis: a historical review.

机构信息

Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, USA.

出版信息

Ann Diagn Pathol. 2012 Jan;16(1):71-8. doi: 10.1016/j.anndiagpath.2011.10.010.

DOI:10.1016/j.anndiagpath.2011.10.010

Abstract

Histochemistry has an interesting history, extending back to ancient times, in some ways. Man has long had a desire to understand the workings of the human body and the roles that various "humors" or chemicals have in those processes. This review traces the evolution of histochemistry as an investigative and diagnostic discipline, beginning with the efforts of medicinal chemists and extending through a period in which histology was increasingly paired with biochemistry. Those developments served as the underpinnings for an eventual marriage of microscopy, chemistry, immunology, and molecular biology, as realized in the current practice of anatomical pathology.

摘要

组织化学有着有趣的历史，可以追溯到古代。人类一直渴望了解人体的运作方式以及各种“体液”或化学物质在这些过程中所起的作用。本综述追溯了组织化学作为一门研究和诊断学科的发展历程，从药用化学家的努力开始，一直延续到组织学与生物化学日益结合的时期。这些发展为显微镜、化学、免疫学和分子生物学的最终结合奠定了基础，正如在当前的解剖病理学实践中所实现的那样。