调节人类对兴奋剂药物反应的遗传因素。
Genetic factors modulating the response to stimulant drugs in humans.
作者信息
Hart Amy B, de Wit Harriet, Palmer Abraham A
出版信息
Curr Top Behav Neurosci. 2012;12:537-77. doi: 10.1007/7854_2011_187.
Abstract
Individuals vary in their responses to stimulant drugs, and several lines of evidence suggest that the basis for this variation is at least partially genetic in origin. Association studies have examined the effects of polymorphisms in specific genes on acute and chronic responses to stimulant drugs. Several of these genetic polymorphisms are also associated with other psychiatric dimensions and disorders.This chapter examines the evidence for genetic associations between the genes that have been most carefully examined for their influence on the response to stimulant drugs.
摘要
个体对兴奋剂药物的反应存在差异，有几条证据表明这种差异的基础至少部分源于遗传。关联研究已经考察了特定基因中的多态性对兴奋剂药物急性和慢性反应的影响。这些基因多态性中的几种还与其他精神维度和疾病有关。本章将审视那些因对兴奋剂药物反应的影响而受到最仔细研究的基因之间存在遗传关联的证据。
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