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本文引用的文献

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OPRM1 gene variants modulate amphetamine-induced euphoria in humans.OPRM1 基因变异可调节人类对安非他命的欣快感。
Genes Brain Behav. 2011 Mar;10(2):199-209. doi: 10.1111/j.1601-183X.2010.00655.x. Epub 2010 Nov 2.
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Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.基于家系的注意缺陷多动障碍全基因组关联扫描研究
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Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.儿童和青少年肥胖和相关特征的遗传易感性：全基因组关联研究确定的基因座的影响。
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PROKR2 is associated with methamphetamine dependence in the Japanese population.PROKR2 与日本人群中的甲基苯丙胺依赖有关。
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The 5-HTTLPR polymorphism of the serotonin transporter gene and short term behavioral response to methylphenidate in children with ADHD.5-羟色胺转运体基因的 5-HTTLPR 多态性与 ADHD 儿童短期行为对哌甲酯的反应。
BMC Psychiatry. 2010 Jun 22;10:50. doi: 10.1186/1471-244X-10-50.
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Genetics of caffeine consumption and responses to caffeine.咖啡因摄入与反应的遗传学研究。
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Lack of association between a 3'UTR VNTR polymorphism of dopamine transporter gene (SLC6A3) and ADHD in a Brazilian sample of adult patients.多巴胺转运体基因（SLC6A3）3'UTR 区 VNTR 多态性与巴西成年 ADHD 患者无关。
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Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population.GRM2 和 HTR2A 与日本人群中甲基苯丙胺所致精神病和精神分裂症的关联分析。
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调节人类对兴奋剂药物反应的遗传因素。

Genetic factors modulating the response to stimulant drugs in humans.

作者信息

Hart Amy B, de Wit Harriet, Palmer Abraham A

出版信息

Curr Top Behav Neurosci. 2012;12:537-77. doi: 10.1007/7854_2011_187.

DOI:10.1007/7854_2011_187
PMID:22261702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3388157/
Abstract

Individuals vary in their responses to stimulant drugs, and several lines of evidence suggest that the basis for this variation is at least partially genetic in origin. Association studies have examined the effects of polymorphisms in specific genes on acute and chronic responses to stimulant drugs. Several of these genetic polymorphisms are also associated with other psychiatric dimensions and disorders.This chapter examines the evidence for genetic associations between the genes that have been most carefully examined for their influence on the response to stimulant drugs.

摘要

个体对兴奋剂药物的反应存在差异，有几条证据表明这种差异的基础至少部分源于遗传。关联研究已经考察了特定基因中的多态性对兴奋剂药物急性和慢性反应的影响。这些基因多态性中的几种还与其他精神维度和疾病有关。本章将审视那些因对兴奋剂药物反应的影响而受到最仔细研究的基因之间存在遗传关联的证据。