Longitudinal genome-wide analysis of patients with chronic lymphocytic leukemia reveals complex evolution of clonal architecture at disease progression and at the time of relapse.
作者信息
Braggio E, Kay N E, VanWier S, Tschumper R C, Smoley S, Eckel-Passow J E, Sassoon T, Barrett M, Van Dyke D L, Byrd J C, Jelinek D F, Shanafelt T D, Fonseca R
出版信息
Leukemia. 2012 Jul;26(7):1698-701. doi: 10.1038/leu.2012.14. Epub 2012 Jan 20.
Abstract
摘要
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Longitudinal genome-wide analysis of patients with chronic lymphocytic leukemia reveals complex evolution of clonal architecture at disease progression and at the time of relapse.慢性淋巴细胞白血病患者的纵向全基因组分析揭示了疾病进展和复发时克隆结构的复杂演变。
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Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival.慢性淋巴细胞白血病中的克隆进化：获得与未突变VH相关的高危基因组畸变、对治疗的抗性及生存期短。
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Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.未经治疗的早期慢性淋巴细胞白血病患者长期随访期间克隆进化的前瞻性评估。
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