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Longitudinal genome-wide analysis of patients with chronic lymphocytic leukemia reveals complex evolution of clonal architecture at disease progression and at the time of relapse.

作者信息

Braggio E, Kay N E, VanWier S, Tschumper R C, Smoley S, Eckel-Passow J E, Sassoon T, Barrett M, Van Dyke D L, Byrd J C, Jelinek D F, Shanafelt T D, Fonseca R

出版信息

Leukemia. 2012 Jul;26(7):1698-701. doi: 10.1038/leu.2012.14. Epub 2012 Jan 20.

DOI:10.1038/leu.2012.14
PMID:22261920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3893815/
Abstract
摘要

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Genetic variegation of clonal architecture and propagating cells in leukaemia.白血病克隆结构和增殖细胞的遗传异质性。
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Intratumoral heterogeneity of HER2/neu expression and its consequences for the management of advanced breast cancer.HER2/neu表达的肿瘤内异质性及其对晚期乳腺癌治疗的影响。
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The genomic landscapes of human breast and colorectal cancers.人类乳腺癌和结直肠癌的基因组图谱。
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Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival.慢性淋巴细胞白血病中的克隆进化：获得与未突变VH相关的高危基因组畸变、对治疗的抗性及生存期短。
Haematologica. 2007 Sep;92(9):1242-5. doi: 10.3324/haematol.10720. Epub 2007 Aug 1.
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Patterns of somatic mutation in human cancer genomes.人类癌症基因组中的体细胞突变模式。
Nature. 2007 Mar 8;446(7132):153-8. doi: 10.1038/nature05610.
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Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.未经治疗的早期慢性淋巴细胞白血病患者长期随访期间克隆进化的前瞻性评估。
J Clin Oncol. 2006 Oct 1;24(28):4634-41. doi: 10.1200/JCO.2006.06.9492.
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Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia.喷司他丁、环磷酰胺和利妥昔单抗联合化疗免疫疗法在既往未治疗的B细胞慢性淋巴细胞白血病中显示出显著的临床活性且伴随毒性较低。
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