Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Copenhagen, The Netherlands.
Dement Geriatr Cogn Disord. 2011;32(4):279-86. doi: 10.1159/000334949. Epub 2012 Jan 19.
To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly.
This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects.
328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01).
The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
探讨胼胝体（CC）组织丢失对老年人认知和运动功能全面受损的影响。
本研究基于白质疏松和残疾（LADIS）研究。在非痴呆的老年受试者中，在基线和 3 年随访时进行认知和运动功能评估以及磁共振成像（MRI）检查。
639 名 LADIS 受试者中有 328 名在基线和 3 年随访时进行了 MRI 检查，从而可以评估 CC。逻辑回归显示，与未转化为痴呆的受试者相比，转化为痴呆的受试者的后 CC 组织丢失率存在差异（p<0.05）。在未转化为痴呆的受试者中，前后 CC 组织丢失与自我感知的记忆障碍显著相关（p<0.05）。CC 组织丢失与单腿站立时间受损也显著相关（p<0.01）。
本项关于 CC 的纵向研究支持胼胝体组织丢失在认知和运动功能全面受损中的作用。
