Ianysheva N Ia, Balenko N V, Chernichenko I A, Bakanova G N, Lemeshko L P
Eksp Onkol. 1990;12(5):21-4.
A modifying influence of ortho-cresol (o-cresol) on the carcinogenic effect of benzo(a)pyrene (B(a)P) in their combined peroral administration to CC57Br mice has been revealed. During the simultaneous administration of the o-cresol (1 mg) and B(a)P (1 mg) the rate of tumours, their multiplicity index, the degree of malignancy increased and the latent period shortened. In case of o-cresol administration before or after B(a)P (in the same doses) the decrease of carcinogenic effect has been revealed. In case of simultaneous administration of 10 mg of the o-cresol and 5 mg of the B(a)P the tumor incidence did not change in comparison with the animals of the control group which received only B(a)P. But their progression was hampered which was confirmed by a decrease of the malignancy rate, frequent occurrence and prolongation of the period of the malignization beginning.
已发现邻甲酚（邻位甲酚）对苯并(a)芘（B(a)P）经口联合给药于CC57Br小鼠时的致癌作用具有修饰影响。在同时给予邻甲酚（1毫克）和B(a)P（1毫克）的过程中，肿瘤发生率、其多发指数、恶性程度增加，潜伏期缩短。在B(a)P之前或之后给予邻甲酚（相同剂量）的情况下，已发现致癌作用降低。在同时给予10毫克邻甲酚和5毫克B(a)P的情况下，与仅接受B(a)P的对照组动物相比，肿瘤发生率没有变化。但它们的进展受到阻碍，这通过恶性率降低、恶性化开始期的频繁出现和延长得到证实。
