Balenko N V, Chernichenko I A, Babiy V F
Ukrainian State Medical Center for Environmental Health, Kiev.
Environ Health Perspect. 1993 Oct;101 Suppl 3(Suppl 3):341-4. doi: 10.1289/ehp.101-1521150.
A modifying influence of ortho-cresol (o-cresol) on the carcinogenic effect of benzo(a)pyrene (BaP) with combined oral administration to CC57Br mice had been found. During simultaneous administration of o-cresol (1 mg) and BaP (1 mg), the incidence of tumors, the multiplicity of tumors, and the degree of malignancy all increased, but the latency was shortened. When o-cresol was administered before or after BaP (in identical doses), the carcinogenic effect was weakened. When o-cresol (10 mg) and BaP (5 mg) were administered simultaneously, the incidence of malignant tumors was similar to controls receiving BaP only (13.8%), indicating inhibition of carcinogenesis.
已发现邻甲酚（邻位甲酚）对苯并(a)芘（BaP）联合口服给予CC57Br小鼠的致癌作用有修饰影响。在同时给予邻甲酚（1毫克）和BaP（1毫克）时，肿瘤发生率、肿瘤多发性和恶性程度均增加，但潜伏期缩短。当在BaP之前或之后给予邻甲酚（相同剂量）时，致癌作用减弱。当同时给予邻甲酚（10毫克）和BaP（5毫克）时，恶性肿瘤发生率与仅接受BaP的对照组相似（13.8%），表明对致癌作用有抑制作用。
