Bershteĭn L M, Zabezhinskiĭ M A, Stukov A N, Kalikhevich V N, Mikheev A M
Eksp Onkol. 1990;12(5):62-4.
It was found that repeated transplantation of ACATOL strain cells resulted in a loss of their sensitivity to growth-stimulating effect of pentagastrin. The effect of gastrin receptor antagonist proglumide, on ACATOL cells growth was inconstant. ACATOL tumor was sensitive to VIP and glucagon in vitro (as shown by adenylate cyclase activity assay), that makes the model promising for selecting potent hormone drugs against colorectal cancer.
研究发现，ACATOL 株细胞的反复移植导致其对五肽胃泌素的生长刺激作用失去敏感性。胃泌素受体拮抗剂丙谷胺对 ACATOL 细胞生长的影响并不稳定。ACATOL 肿瘤在体外对血管活性肠肽（VIP）和胰高血糖素敏感（通过腺苷酸环化酶活性测定显示），这使得该模型有望用于筛选抗结直肠癌的有效激素药物。
