Bershteĭn L M, Pravosudov I V, Kovaleva I G, Kriukova O G
Vopr Onkol. 1992;38(1):60-9.
Sensitivity of 142 human large bowel malignancies to gastroenteropancreatic hormones (VIP, glucagon and pentogastrin) and calcitonin was studied using in vitro adenylate cyclase reaction of tumor. At least 40-55% of the tumors proved hormone sensitive. Heteroresponse (reaction to calcitonin) was most characteristic for colonic tumors whereas weak reaction to VIP and glucagon-for rectal neoplasms. A certain relationship was established between adenylate cyclase reaction to hormone stimulation, on the one hand, and peculiarities of tumor (degree of cell differentiation) and the body (gender), on the other. In patients who survived over 4 years, tumor adenylate cyclase had initially been more sensitive to hormone stimulation than in those who died over that period. It is concluded that tumor adenylate cyclase reaction to hormone stimulation is quite a reliable test for evaluating hormone sensitivity of large bowel tumors and, possibly, for choosing hormonal therapy.
利用肿瘤的体外腺苷酸环化酶反应，研究了142例人大肠恶性肿瘤对胃肠胰激素（血管活性肠肽、胰高血糖素和五肽胃泌素）及降钙素的敏感性。至少40% - 55%的肿瘤被证明对激素敏感。异质性反应（对降钙素的反应）在结肠肿瘤中最为典型，而对血管活性肠肽和胰高血糖素反应较弱的则是直肠肿瘤。一方面，肿瘤腺苷酸环化酶对激素刺激的反应与肿瘤的特性（细胞分化程度）和机体（性别）之间存在一定关系。存活超过4年的患者，其肿瘤腺苷酸环化酶最初对激素刺激的敏感性高于在此期间死亡的患者。结论是，肿瘤腺苷酸环化酶对激素刺激的反应是评估大肠肿瘤激素敏感性以及可能选择激素治疗的相当可靠的检测方法。
