Kim Jae Jun, Park Jae-Kil, Wang Young-Pil
Department of Thoracic and Cardiovascular Surgery, College of Medicine, The Catholic University of Korea, Korea.
Korean J Thorac Cardiovasc Surg. 2011 Apr;44(2):159-64. doi: 10.5090/kjtcs.2011.44.2.159. Epub 2011 Apr 14.
Renal cell carcinoma has shown less response to systemic therapies including chemotherapy, radiation, and immunotherapy than other cancers. Surgery has therefore become an important treatment tool. The protocol for treatment is the same for pulmonary metastasis of renal cell carcinoma. We performed surgery for pulmonary metastatic renal cell carcinomas and analyzed the results.
We retrospectively analyzed 15 patients who had undergone pulmonary metastasectomy from renal cell carcinoma at our hospital from January 2005 to December 2009.
No patients had extrathoracic metastatsis. The mean age was 60.2 years (range 35~73). There were 12 male and 3 female patients. The number of synchronous and metachronous patients were 8 and 7, respectively. The mean survival times of synchronous and metachronous patients were 32.6 and 42.9 months, respectively. 6 patients had single lesions and 9 patients had multiple (more than 3) lesions. The surgical procedures included wedge resection (10), lobectomy (2), wedge resection with segmentectomy (2), and segmentectomy (1). Median observation and survival time were 54.1 and 34.9 months. The 1-year and 3-year survival rates were 80% and 50%, respectively.
Pulmonary resection for pulmonary metastatic renal cell carcinoma was found to be a safe and effective treatment modality when complete resection was performed.
与其他癌症相比，肾细胞癌对包括化疗、放疗和免疫治疗在内的全身治疗反应较差。因此，手术已成为一种重要的治疗手段。肾细胞癌肺转移的治疗方案与此相同。我们对肾细胞癌肺转移患者进行了手术，并分析了结果。
我们回顾性分析了2005年1月至2009年12月在我院接受肾细胞癌肺转移切除术的15例患者。
所有患者均无胸外转移。平均年龄为60.2岁（范围35~73岁）。男性12例，女性3例。同时性和异时性转移患者分别为8例和7例。同时性和异时性转移患者的平均生存时间分别为32.6个月和42.9个月。6例患者为单发转移灶，9例患者为多发（超过3个）转移灶。手术方式包括楔形切除术（10例）、肺叶切除术（2例）、楔形切除术联合肺段切除术（2例）和肺段切除术（1例）。中位观察和生存时间分别为54.1个月和34.9个月。1年和3年生存率分别为80%和50%。
对于肾细胞癌肺转移，当进行完整切除时，肺切除术是一种安全有效的治疗方式。
