Organic Chemistry Institute and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Münster, Germany.
Langmuir. 2012 Apr 3;28(13):5527-38. doi: 10.1021/la204721x. Epub 2012 Feb 7.
In this Feature Article we describe recent progress in covalent surface patterning by microcontact chemistry. Microcontact chemistry is a variation of microcontact printing based on the transfer of reactive "ink" molecules from a microstructured, elastomeric stamp onto surfaces modified with complementary reactive groups, leading to a chemical reaction in the area of contact. In comparison with other lithographic methods, microcontact chemistry has a number of advantageous properties including very short patterning times, low consumption of ink molecules, high resolution and large area patterning. During the past 5 years we and many others have investigated a set of different reactions that allow the modification of flat and also spherical surfaces in an effective way. Especially click-type reactions were found to be versatile for substrate patterning by microcontact chemistry and were applied for chemical modification of reactive self-assembled monolayers and polymer surfaces. Microcontact chemistry has already found broad application for the production of functional surfaces and was also used for the preparation of DNA, RNA, and carbohydrate microarrays, for the immobilization of proteins and cells and for the development of sensors.
在这篇专题文章中，我们描述了微接触化学在共价表面图案化方面的最新进展。微接触化学是基于微接触印刷的一种变体，它基于将反应性“墨水”分子从微结构化的弹性印章转移到用互补反应性基团修饰的表面上，从而导致接触区域的化学反应。与其他光刻方法相比，微接触化学具有许多有利的特性，包括非常短的图案化时间、墨水分子的低消耗、高分辨率和大面积图案化。在过去的 5 年中，我们和许多其他人研究了一组不同的反应，这些反应可以有效地修饰平面和球形表面。特别是点击型反应被发现对于微接触化学的基底图案化非常通用，并被应用于反应性自组装单层和聚合物表面的化学修饰。微接触化学已经在功能表面的制备中得到了广泛的应用，也被用于 DNA、RNA 和碳水化合物微阵列的制备、蛋白质和细胞的固定化以及传感器的开发。
