Tran Vuong Thi, Ishizaki Azumi, Nguyen Cuong Hung, Hoang Huyen Thi Thanh, Pham Hung Viet, Bi Xiuqiong, Van Pham Thuc, Ichimura Hiroshi
Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Japan.
AIDS Res Hum Retroviruses. 2012 Oct;28(10):1349-51. doi: 10.1089/aid.2012.0006. Epub 2012 Mar 6.
We reported previously that the prevalence of drug-resistant HIV-1 among antiretroviral therapy (ART)-naive individuals in Northern Vietnam was 2.9% in 2007 and 6.2% in 2008. To investigate the continuing trend of prevalence, we collected plasma samples from 958 individuals in Hai Phong and Hanoi in 2009, extracted viral RNA from HIV-1 antibody-positive samples, and analyzed them genetically. HIV-1 antibody prevalence was 26.8% in injecting drug users (n=302), 13.4% in female sex workers (n=284), 0.5% in blood donors (n=206), and 0.6% in pregnant women (n=166). All HIV-1 strains were CRF01_AE. Nonnucleoside reverse-transcriptase inhibitor resistance mutations were found in two (2.0%) of the 102 successfully analyzed cases (one case with the Y181C and one with the K101E). No nucleoside reverse-transcriptase inhibitor resistance or protease inhibitor resistance mutations were detected. The prevalence of circulating ART-resistant HIV-1 in Northern Vietnam did not increase from 2007 to 2009, although the rate of ART coverage did increase.
我们之前报道过，2007年越南北方未接受抗逆转录病毒治疗（ART）的个体中耐药HIV-1的流行率为2.9%，2008年为6.2%。为调查流行率的持续趋势，我们于2009年从海防和河内的958名个体中采集血浆样本，从HIV-1抗体阳性样本中提取病毒RNA，并进行基因分析。注射吸毒者（n = 302）中HIV-1抗体流行率为26.8%，女性性工作者（n = 284）中为13.4%，献血者（n = 206）中为0.5%，孕妇（n = 166）中为0.6%。所有HIV-1毒株均为CRF01_AE。在102例成功分析的病例中，有两例（2.0%）发现了非核苷类逆转录酶抑制剂耐药突变（一例为Y181C，一例为K101E）。未检测到核苷类逆转录酶抑制剂耐药或蛋白酶抑制剂耐药突变。尽管ART覆盖率有所提高，但2007年至2009年期间，越南北方循环ART耐药HIV-1的流行率并未增加。
