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越南胡志明市200名未经治疗个体的1型艾滋病毒分离株：ANRS 1257研究。CRF01_AE型占主导且存在对抗逆转录病毒药物的主要耐药突变。

HIV type 1 isolates from 200 untreated individuals in Ho Chi Minh City (Vietnam): ANRS 1257 Study. Large predominance of CRF01_AE and presence of major resistance mutations to antiretroviral drugs.

作者信息

Lan Nguyen Thi Hoang, Recordon-Pinson Patricia, Hung Pham Van, Uyen Nguyen Thi Vy, Lien Truong Thi Xuan, Tien Huynh Tan, Garrigue Isabelle, Schrive Marie-Hélène, Pellegrin Isabelle, Lafon Marie-Edith, Aboulker Jean-Pierre, Barré-Sinousi Françoise, Fleury Hervé J

机构信息

Centre de Medecine Preventive, Ho Chi Minh Ville (HCMV), Viet Nam.

出版信息

AIDS Res Hum Retroviruses. 2003 Oct;19(10):925-8. doi: 10.1089/088922203322493111.

DOI:10.1089/088922203322493111
PMID:14601592
Abstract

HIV-1 isolates from 200 untreated patients recruited in 2001 and 2002 in the south part of Vietnam and particularly in Ho Chi Minh City were sequenced in the RT, protease, and env genes. Out of 200 isolates 198 belonged to CRF01_AE while only one subtype B and one intersubtype (B-CRF01_AE) recombinant could be observed. Of the isolates 6.5% had major resistance mutations to antiretroviral drugs.

摘要

对2001年和2002年在越南南部尤其是胡志明市招募的200名未经治疗的患者的HIV-1分离株进行了逆转录酶（RT）、蛋白酶和包膜（env）基因测序。在200株分离株中，198株属于CRF01_AE，仅观察到1株B亚型和1株B-CRF01_AE重组亚型。在这些分离株中，6.5%对抗逆转录病毒药物有主要耐药突变。

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