越南北方海防市HIV-1流行率及传播性耐药HIV-1发生率的变化

Change in the Prevalence of HIV-1 and the Rate of Transmitted Drug-Resistant HIV-1 in Haiphong, Northern Vietnam.

作者信息

Pham Hung Viet, Ishizaki Azumi, Nguyen Cuong Hung, Saina Matilda Chelimo, Hoang Huyen Thi Thanh, Tran Vuong Thi, Bi Xiuqiong, Pham Thuc Van, Ichimura Hiroshi

机构信息

1 Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University , Kanazawa, Japan .

2 Hai Phong Medical University , Hai Phong, Vietnam .

出版信息

AIDS Res Hum Retroviruses. 2015 Jul;31(7):757-9. doi: 10.1089/AID.2015.0071. Epub 2015 Jun 15.

DOI:10.1089/AID.2015.0071

PMID:25970090

Abstract

We previously reported a significant decrease in HIV-1 prevalence, with no increase in drug-resistant HIV-1 among injecting drug users (IDU), female sex workers (FSW), and blood donors (BD), in Haiphong, Vietnam, from 2007 to 2009. In 2012, 388 IDU, 51 FSW, and 200 BD were recruited for further analysis. None had a history of antiretroviral treatment. From 2007 to 2012, HIV-1 prevalence was reduced from 35.9% to 18.6% (p<0.001), 23.1% to 9.8% (p<0.05), and 2.9% to 1% (p=0.29) in IDU, FSW, and BD, respectively. Of 79 anti-HIV-1 antibody-positive samples, 61 were successfully analyzed for the pol-reverse transcriptase (RT) region. All HIV-1 strains were CRF01_AE. Nonnucleoside RT inhibitor-resistant mutations, Y181C/I, were detected in three subjects; one had the nucleoside RT inhibitor-resistant mutations L74V and M184V and one had E138K. The prevalence of transmitted drug-resistant HIV-1 in Haiphong increased slightly from 1.8% in 2007 to 6.6% in 2012 (p=0.06).

摘要

我们之前报告过，2007年至2009年期间，越南海防市注射吸毒者（IDU）、女性性工作者（FSW）和献血者（BD）中HIV-1感染率显著下降，且耐药HIV-1未增加。2012年，招募了388名注射吸毒者、51名女性性工作者和200名献血者进行进一步分析。他们均无抗逆转录病毒治疗史。2007年至2012年期间，注射吸毒者、女性性工作者和献血者中HIV-1感染率分别从35.9%降至18.6%（p<0.001）、从23.1%降至9.8%（p<0.05）、从2.9%降至1%（p=0.29）。在79份抗HIV-1抗体阳性样本中，61份成功分析了pol-逆转录酶（RT）区域。所有HIV-1毒株均为CRF01_AE型。在三名受试者中检测到非核苷类逆转录酶抑制剂耐药突变Y181C/I；一名受试者有核苷类逆转录酶抑制剂耐药突变L74V和M184V，一名受试者有E138K。海防市传播性耐药HIV-1的感染率从2007年的1.8%略有上升至2012年的6.6%（p=0.06）。