ADAMTS-4 的体外抗血管生成特性。
Anti-angiogenic properties of ADAMTS-4 in vitro.
机构信息
Academic Unit of Molecular Medicine and Rheumatology, University of Sheffield Medical School, Sheffield, UK.
出版信息
Int J Exp Pathol. 2012 Feb;93(1):70-7. doi: 10.1111/j.1365-2613.2011.00802.x.
Abstract
Angiogenesis is an indispensable mechanism in development and in many pathologies, including cancer, synovitis and aberrant wound healing. Many angiogenic stimulators and inhibitors have been investigated, and some have progressed to the clinic. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a group of multifunctional proteinases. ADAMTS-1 and ADAMTS-8 have been reported to be anti-angiogenic. Here, we provide evidence that ADAMTS-4, like ADAMTS-1, is expressed by endothelial cells and binds to vascular endothelial groth factor (VEGF). Moreover, ADAMTS-4 inhibited human dermal microvascular endothelial cells (HuDMEC) VEGF-stimulated VEGF receptor (R) R2 phosphorylation, differentiation and migration, suggesting that ADAMTS-4 may be a novel anti-angiogenic molecule.
摘要
血管生成是发育和许多病理学（包括癌症、滑膜炎和异常伤口愈合）中不可缺少的机制。已经研究了许多血管生成刺激剂和抑制剂，其中一些已经进入临床阶段。解整合素和金属蛋白酶与血小板反应蛋白基序（ADAMTS）是一组多功能蛋白酶。已经报道 ADAMTS-1 和 ADAMTS-8 具有抗血管生成作用。在这里，我们提供的证据表明，ADAMTS-4 与 ADAMTS-1 一样，由内皮细胞表达并与血管内皮生长因子（VEGF）结合。此外，ADAMTS-4 抑制人真皮微血管内皮细胞（HuDMEC）VEGF 刺激的 VEGF 受体（R）R2 磷酸化、分化和迁移，表明 ADAMTS-4 可能是一种新型的抗血管生成分子。
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